Sertima 25mg Tablet


Sertima 25mg is a selective serotonin reuptake inhibitor (SSRI) developed by Intuspharma and the generic version of Sertima 25mg.

This medicine strongly inhibits the reuptake of serotonin in the brain and increases the amount of serotonin, thereby showing antidepressant and anti-anxiety effects.

Compared to other drugs, drug interactions are less likely to occur, so it is used to improve depression/depressive state, panic disorder, and post-traumatic stress disorder (PTSD).

Improvement of depression, panic disorder, anxiety disorder, etc.
Active ingredient Sertraline hydrochloride
Estimated delivery days 7~14 days
Target gender unisex
Pharmaceutical company Intas Pharma

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Characteristics of Sertima 25mg

Sertima 25mg is a third-generation antidepressant containing sertraline, the strongest active ingredient. Antidepressant, anti-anxiety/panic disorder treatment of anxiety disorders (post-traumatic stress disorder (PTSD), generalized anxiety disorder, obsessive-compulsive disorder, social anxiety disorder), premenstrual dysphoric disorder, and bipolar disorder It is a widely used drug for Compared to conventional antidepressants, it is characterized by significantly reduced side effects such as dry mouth, constipation, dizziness, and lightheadedness.

A third-generation antidepressant that improves a wide range of symptoms such as depression and panic disorder.
  • Selectively maintains brain levels of serotonin associated with depression.
  • It is effective not only for depression but also for a wide range of symptoms such as panic disorder.
  • It can be used economically because it is a generic drug.


  • depression
  • restless mental stability

Sertima 25mg is an antidepressant and tranquilizer classified as a selective serotonin reuptake inhibitor (SSRI), and improves depression and mood disorders by increasing serotonin. The effect of increasing serotonin is the strongest among SSRIs, and it can be expected to improve not only depression but also various symptoms such as menstrual mood anxiety disorder, insomnia, obsessive-compulsive disorder, and panic disorder.

About Sertima 25mg

Sertima 25mg is a third-generation antidepressant that inhibits serotonin reuptake. By inhibiting the reuptake of serotonin and maintaining the concentration of serotonin in the brain, anxiety and pessimistic feelings become positive, and depressive symptoms are improved.

The main ingredient is sertraline hydrochloride, which has the strongest serotonin reuptake inhibitory effect among third-generation antidepressants, and treatment using sertraline hydrochloride has a low possibility of recurrence, according to the Ministry of Health, Labor and Welfare and the FDA (US Food and Drug Administration).

It is a highly reliable antidepressant approved by In addition, since it is a generic drug of the original drug, Sertima 25mg, it can be purchased at about half the price of the original drug, making it economical to use.

Improves depressive symptoms by maintaining brain concentration of serotonin

The neurotransmitters serotonin and norepinephrine are involved in depression. Serotonin is a substance that gives people a sense of security and makes them feel relaxed. On the other hand, noradrenaline is a substance that controls motivation, activity, aggressiveness, thinking ability, and concentration.

Fall into depression. Depression is thought to be caused by a decrease in the amount of these substances due to stress, etc., resulting in a variety of symptoms.

The active ingredient of Sertima 25mg, sertraline hydrochloride, strongly inhibits the reuptake of serotonin and can maintain the concentration of serotonin in the brain at a certain level. It is also effective not only for depression and anxiety disorders, but also for menstrual mood anxiety disorder and insomnia, making it a popular remedy for stabilizing irritable moods.

Changes in Antidepressants

Since iproniazid was first developed as an antidepressant in 1952, various antidepressants that are effective in treating depressive symptoms and have few side effects have been developed and improved. These drugs are classified according to the structure and effect of the active ingredient, and are currently called 1st to 4th generation drugs.

First, tricyclic drugs, including iproniazid, were developed as the first generation. While these have definite antidepressant effects, side effects include anticholinergic effects (dry mouth and constipation) and cardiotoxicity that adversely affects the heart. Then came the second generation of improved tricyclic, tetracyclic, and bicyclic systems, which had slightly weaker antidepressant effects than the first generation, but had less anticholinergic effects and cardiotoxicity than the first generation. it was done.

After that, SSRIs (selective serotonin reuptake inhibitors) will appear as the third generation. The antidepressant effect of the 3rd generation is slightly weaker than that of the 2nd generation, but the anticholinergic effects and cardiotoxicity are greatly reduced. Then, SNRIs (serotonin and noradrenaline reuptake inhibitors) were developed as the fourth generation, with antidepressant effects comparable to the first generation and side effects comparable to the third generation. Sertima 25mg is classified as a third-generation SSRI antidepressant.

Please be aware of side effects and contraindicated drugs when taking this medicine.

Taking Sertima 25mg can improve depression and anxiety disorders. On the other hand, side effects include nausea, dry mouth, headache, and diarrhea. Compared to the original drug, Sertima 25mg, there are fewer reports of side effects, but if you feel unwell after taking it, consult your doctor. In addition, pimozide, a schizophrenia drug, and similar antidepressants are prohibited as concomitant drugs, so please consult your doctor before using them.

How to take Sertima 25mg

1 Dose
1 tablet (25mg as “sertraline hydrochloride”)
Number of doses per day
up to 1 time
Upper limit of dosage

Stick to the dose and take daily after dinner

Take 25 to 100mg of Sertima 25mg once a day after dinner with water or lukewarm water. The initial dosage is 25mg, and if no effects or side effects are observed, the dosage can be increased to a maximum of 100mg per day. If you miss a dose, take it as soon as you remember, but if it is almost time for the next dose, skip it. Do not take 2 doses at once.

Sertima 25mg Side Effects

Major side effects
  • nausea
  • somnolence
  • dry mouth
  • headache
  • diarrhea
  • dizzy
  • rash
  • hives
  • pruritus
  • facial edema
  • Periorbital edema
  • photosensitivity reactions, etc.
Rare side effects
  • serotonin syndrome
  • malignant syndrome
  • convulsions
  • coma
  • Syndrome of inappropriate secretion of antidiuretic hormone (SIADH)

Sertima 25mg Precautions

Careful administration
The following people should be careful when taking this medicine.

  • Those with liver dysfunction
  • Manic-depressive patients
  • Patients with a history of suicidal ideation or suicide attempt, patients with suicidal ideation
  • Those who are predisposed to organic brain disorders or schizophrenia
  • Those with comorbid disorders with high impulsivity
  • Convulsive diseases such as epilepsy, or those with a history of these
  • Patients with QT prolongation or a history of it, patients taking drugs known to cause QT prolongation, patients with marked bradycardia or hypokalemia
  • Patients concomitantly taking drugs that increase the risk of bleeding, those with bleeding tendency or bleeding predisposition
  • Those with glaucoma or a history of it
  • Elderly people (65 years old and over)
  • Those who are pregnant or may become pregnant
  • breastfeeding
Persons who should not take
The following people cannot use this medicine.

  • Those with a history of hypersensitivity to the ingredients of Sertima 25mg
  • Those who are taking MAO inhibitors (selegiline hydrochloride, rasagiline mesylate) or within 2 weeks after stopping administration
  • Those taking pimozide
Precautions for combined use
Caution should be exercised when using this medicine in combination with the following medicines.

  • Methylthioninium chloride hydrate (methylene blue)
  • Linezolid
  • 5-HT1B/1D receptor agonists (sumatriptan succinate, zolmitriptan, eletripta)
  • Preparations containing tramadol, methadone, pentazocine, L-tryptophan (amino acid preparations, enteral nutritional supplements)
  • St. John’s wort-containing foods
  • lithium carbonate
  • Tricyclic antidepressants (clomipramine hydrochloride, imipramine hydrochloride, amitriptyline hydrochloride)
  • Warfarin
  • Drugs that increase bleeding tendency (atypical antipsychotics, phenothiazine antipsychotics, tricyclic antidepressants, non-steroidal anti-inflammatory drugs such as aspirin, warfarin, etc.)
  • Hypoglycemic drug (tolbutamide)
  • Cimetidine
  • alcohol (drinking)
Contraindications for co-administration
Avoid using this medicine in combination with the following medicines.

  • monoamine oxidase (MAO) inhibitors (selegiline hydrochloride (FP), rasagiline mesylate (Agilect)
  • pimozide (orup)

How to store Sertima 25mg

  • Avoid direct sunlight and store at room temperature.
    It does not need to be refrigerated, but should not be stored in a hot or humid place.
  • Keep out of reach of small children.
    Please store it carefully so that children do not take it by mistake.


Country of origin

Estimated time of arrival
7-14 days

  • Delivery may be delayed due to weather in the country of origin or holidays of vendors in the country of origin.
  • Delivery may be delayed in some areas such as remote islands and remote islands.

Additional information

Pack Size

100 Tablet/s, 200 Tablet/s, 300 Tablet/s


Intas Pharmaceutical


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