Toficalm 100mg Tablet


Toficalm 100mg is an autonomic nerve regulating drug developed by Sun Pharma and is a generic drug of Grandaxin.

Autonomic nerves refer to sympathetic nerves and parasympathetic nerves, and the symptoms that come from this imbalance in the autonomic nerves appear as irritability, palpitations, sweating, headaches, malaise, and decreased motivation.

Improvement of autonomic imbalance, menopausal disorders, etc.
Active ingredient Tofisopam
Estimated delivery days 7~14 days
Target gender unisex
Pharmaceutical company Sun Pharma

Free shipping on orders over $100!

  • Check Mark Satisfaction Guaranteed
  • Check Mark No Hassle Refunds
  • Check Mark Secure Payments
  • Visa Card
  • MasterCard
  • American Express
  • Discover Card

Available Options:


About Toficalm 100mg

Gentle effect with low risk of dependence and side effects! Body-friendly autonomic nerve regulator
  • The effect is mild, so it is safe even for those who are taking anti-anxiety drugs for the first time.
  • It is characterized by its fast-acting, short-acting, and less likely to become addictive.
  • A highly safe benzodiazepine autonomic nerve regulator.

Toficalm 100mg is an autonomic nerve regulator manufactured by Sun Pharma, an Indian pharmaceutical company, and is a generic drug of Grandaxin. Dosages include 50mg and 100mg tablets. By taking this medicine 3 times a day, it regulates the disorder of the autonomic nervous system and alleviates various symptoms such as headache and palpitations caused by anxiety and tension.

Among benzodiazepine anti-anxiety drugs, it is in the mild category and is recommended for those whose main symptoms are mild autonomic nervous system symptoms.

Features of Toficalm 100mg

The best feature of Toficalm 100mg is that it has a weak inhibitory effect on the central nervous system and a mild effect.

In benzodiazepines, including Toficalm 100mg, central nervous system depressant effects can be broadly classified into four types. They are anxiolytic, hypnotic, muscle relaxant and anticonvulsant.

The effects of benzodiazepines, which have a strong inhibitory effect, are of course easy to understand, but there is also a risk that strong inhibitory effects may appear as side effects.

If the sedative or hypnotic effect is too strong, it may cause symptoms such as drowsiness and lightheadedness, and if the muscle relaxant effect is too strong, you may feel fatigue and weakness.

On the other hand, all of the inhibitory effects of Toficalm 100mg are considered to be very weak among benzodiazepines. Therefore, it is recommended to take it for those with mild symptoms, and some people may not feel a dramatic effect depending on the type and degree of autonomic imbalance symptoms.

If you feel that taking Toficalm 100mg is not effective enough, we recommend that you consult your doctor or pharmacist once.

Benzodiazepines are safer than barbiturates

Currently, benzodiazepines, including Toficalm 100mg, are the mainstream anti-anxiety drugs and sleeping drugs.

Since their development in the early 20th century, barbiturates have been widely prescribed for more than 50 years.

Benzodiazepines were developed as safer drugs to eliminate the disadvantages.

The biggest difference between barbiturates and benzodiazepines is the binding site of the active ingredient. The active ingredients of benzodiazepines bind to GABAA receptors, which are responsible for opening ion channels.

As a result, GABAA receptors increase the permeability of ions, so the action of the active ingredient is indirect, and once the benzodiazepine binding site becomes saturated, it cannot bind any more. Barbiturates, on the other hand, bind directly to ion channels.

Unlike the benzodiazepine site of the GABAA receptor, this site does not become saturated, so the inhibitory effect increases in proportion to the increase in dose. This leads to respiratory depression with high doses of barbiturates.

Among the highly safe benzodiazepines, Toficalm 100mg has a particularly weak effect, so even people taking anti-anxiety drugs for the first time can use it with peace of mind.

It is a short-acting, fast-acting, and sharply effective drug.

Toficalm 100mg is classified as a benzodiazepine. Benzodiazepines are mainly prescribed as sleeping pills, and are further divided into short-acting, intermediate-acting, and long-acting according to their duration of action.

Toficalm 100mg is a short-acting autonomic nervous system regulating agent that reaches maximum blood concentration in one hour after administration and has a half-life (the time it takes for the blood concentration of the active ingredient to halve) of 4 to 5 hours. In other words, if you are an early person, the effect will appear in about 15 to 30 minutes after taking it, and in about 12 hours, all the medicinal ingredients will be gone from the body.

Short-acting benzodiazepines are generally considered to be addictive. However, in the case of Toficalm 100mg, the central nervous system depressant effect is very modest in the first place, so it can be said that it is also an advantage that it is difficult to become dependent.

In addition, since the active ingredient is rapidly metabolized, even if side effects appear, they will subside relatively quickly.

In this way, Toficalm 100mg can be said to be an easy-to-use autonomic nervous system regulating agent for those whose symptoms are relatively mild and mainly related to the autonomic nervous system.

Effects of toficalm 100mg


Relief of headache, dull headache, malaise, palpitations, sweating, etc. in autonomic imbalance, head injury/neck injury, menopausal disorder/ovarian deficiency symptoms.

Toficalm 100mg has the effect of relieving various symptoms such as headaches caused by psychological stress, and relieving anxiety, tension, and frustration.

In addition, it is also indicated for menopausal disorders and symptoms of ovarian deficiency caused by hormonal imbalance (menopausal disorders-like symptoms that can occur when both ovaries are removed by surgery for uterine cancer or ovarian cancer).

All of these are symptoms of autonomic imbalance caused by an imbalance between the sympathetic and parasympathetic nervous systems. Toficalm 100mg exerts an ameliorating effect on both stress- and hormone-induced autonomic imbalance.

How to take Toficalm 100mg

1 Dose
1/2 to 1 tablet (50mg as tofisopam)
When to take
fixed time every day
Number of doses per day
3 times
Interval between doses
8 hours

About when to take

In general, for adults, take 1/2 tablet or 1 tablet (50mg of Tofisopam) three times a day at a fixed time every day. The dose can be increased or decreased according to age and symptoms. If you forget to take a dose, take it as soon as you realize you forgot to take it. Also, do not take 2 doses at once.

Toficalm 100mg is a medicine that is not affected by food. As long as it is taken at the same time every day, it does not matter whether it is taken before or after meals.

However, it should be noted that the central nervous system depressant effect may be additively enhanced when Toficalm 100mg is used in combination with alcohol.

Therefore, refrain from drinking alcohol while taking Toficalm 100mg, and be sure to take it with cold or lukewarm water.

In addition, the hypnotic effect of Toficalm 100mg may make you feel very drowsy. Avoid driving a car or performing dangerous activities while taking Toficalm 100mg.

Active Ingredients of Toficalm 100mg

Tofisopam stimulates intracellular Cl- channel opening and inhibits neuronal function

Tofisopam, the active ingredient of Toficalm 100mg, is classified as a benzodiazepine drug and has a central nervous system depressant effect.

In order for the brain to enter a neurosuppressive state, Cl- (chloride ions) must flow into the cells and become negatively inclined (hyperpolarization). GABA receptors (GABAA receptors), which are inhibitory neurotransmitters that increase Cl- permeability, are receptors containing ion channels such as Cl-, and are widely distributed mainly in the brain. Binding of tofisopam to the benzodiazepine site of the GABAA receptor potentiates the Cl-permeability of GABA.

As a result, cells are filled with Cl- and become hyperpolarized, making it difficult for the brain to receive external stimuli, suppressing excitation and reducing nervous tension.

toficalm 100mg side effects

Major side effects

Headache, dizziness, drowsiness, lightheadedness, nausea, abdominal pain, diarrhea, etc.

Toficalm 100mg is less likely to cause side effects than other benzodiazepines, but if you experience symptoms such as headache, dizziness, or nausea, stop taking Toficalm 100mg and consult your doctor or pharmacist.

Rare side effects

Dependence, fatigue, weakness, etc.

Toficalm 100mg has the characteristic of being very gradual in its effect, and it can be said that the frequency of side effects such as dependence is rare. However, if you experience physical discomfort such as fatigue or weakness, stop taking Toficalm 100mg and consult a doctor.

Precautions for Toficalm 100mg

Careful administration
  • People with acute angle-closure glaucoma
  • people with severe myasthenia
  • people with cerebral organic disorders
  • People with moderate or severe respiratory failure
  • Elderly people aged 65 and over
  • pregnant person
  • People taking central nervous system depressants (phenothiazine derivatives, barbituric acid derivatives, etc.)
  • People taking tacrolimus hydrate
Persons who should not take
  • Persons with a history of hypersensitivity to tofisopam
  • People taking romitapide mesylate
  • breastfeeding person
Contraindicated drugs
  • Lomitapide mesylate


Country of origin

Estimated time of arrival
7-14 days

  • Delivery may be delayed due to weather in the country of origin or holidays of vendors in the country of origin.
  • Delivery may be delayed in some areas such as remote islands and remote islands.

Additional information

Pack Size

100 Tablet/s, 200 Tablet/s, 300 Tablet/s


Sun Pharmaceutical


There are no reviews yet.

Be the first to review “Toficalm 100mg Tablet”

Your email address will not be published. Required fields are marked *